Protein Details: Short transient receptor potential channel 6

Protein ID

ICDB_Pro_1712

Protein Name

Short transient receptor potential channel 6

Gene Name

TRPC6; TRP6

Organism

Homo sapiens (Human)

Length

931 amino acids

AlphaFoldDB

AF-Q9Y210-F1-model_v4.pdb

Function

Sequence

MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR

PDB Structures

5YX9 6UZ8 6UZA 7A6U 7DXF 7DXG

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Focal Segmental Glomerulosclerosis 2 and Nephrotic Syndrome

Location

Expressed primarily in placenta; lung; spleen; ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. . . .

DOI ID

10.1038/16711; 10.1159/000015165; 10.1074/jbc.m003408200; 10.1101/gr.2596504; 10.1074/jbc.m302983200; 10.1074/jbc.m500391200; 10.1016/j.ceca.2007.07.009; 10.1021/pr0704130; 10.1038/ng1592; 10.1126/science.1106215; 10.1016/j.mrfmmm.2008.11.021; 10.1093/ndt/gfp229; 10.1371/journal.pone.0007771; 10.2215/cjn.01190210; 10.2215/cjn.07830910; 10.5414/cn107320; 10.1093/ndt/gfr202; 10.1038/ki.2012.349; 10.1093/ndt/gfs572; 10.1681/asn.2015030318

RefSeq

NP_004612.2 [Q9Y210-1]; XP_016873710.1 [Q9Y210-2];